Autophagy in Vascular Disease
نویسندگان
چکیده
منابع مشابه
Autophagy in vascular disease.
Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreover, autophagy is stimulated by many stress-related stimuli in the arterial wall to protect endothe...
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In response to hypertension, the heart manifests robust hypertrophic growth, which offsets load-induced elevations in wall stress. If sustained, this hypertrophic response is a major risk factor for systolic dysfunction and heart failure. Extensive research efforts have focused on the progression from hypertrophy to failure; however, precise understanding of underlying mechanisms remains elusiv...
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ژورنال
عنوان ژورنال: Proceedings of the American Thoracic Society
سال: 2010
ISSN: 1546-3222
DOI: 10.1513/pats.200909-100js